Ontology highlight
ABSTRACT:
SUBMITTER: Ju S
PROVIDER: S-EPMC3082520 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Ju Shulin S Tardiff Daniel F DF Han Haesun H Divya Kanneganti K Zhong Quan Q Maquat Lynne E LE Bosco Daryl A DA Hayward Lawrence J LJ Brown Robert H RH Lindquist Susan S Ringe Dagmar D Petsko Gregory A GA
PLoS biology 20110426 4
FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant forms of FUS/TLS traffic to, and form inclusions in, the cytoplasm of affected spinal motor neurons or glia. Here we report a yeast model of human FUS/TLS expression that recapitulates multiple salient features of the pathology of the disease-causing mutant proteins, including nu ...[more]