Ontology highlight
ABSTRACT:
SUBMITTER: Raczynska KD
PROVIDER: S-EPMC4787759 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Raczynska Katarzyna Dorota KD Ruepp Marc-David MD Brzek Aleksandra A Reber Stefan S Romeo Valentina V Rindlisbacher Barbara B Heller Manfred M Szweykowska-Kulinska Zofia Z Jarmolowski Artur A Schümperli Daniel D
Nucleic acids research 20150806 20
Replication-dependent histone genes are up-regulated during the G1/S phase transition to meet the requirement for histones to package the newly synthesized DNA. In mammalian cells, this increment is achieved by enhanced transcription and 3' end processing. The non-polyadenylated histone mRNA 3' ends are generated by a unique mechanism involving the U7 small ribonucleoprotein (U7 snRNP). By using affinity purification methods to enrich U7 snRNA, we identified FUS/TLS as a novel U7 snRNP interacti ...[more]