Ontology highlight
ABSTRACT:
SUBMITTER: Blouin S
PROVIDER: S-EPMC3082890 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Blouin Simon S Chinnappan Raja R Lafontaine Daniel A DA
Nucleic acids research 20101217 8
The Bacillus subtilis lysC lysine riboswitch modulates its own gene expression upon lysine binding through a transcription attenuation mechanism. The riboswitch aptamer is organized around a single five-way junction that provides the scaffold for two long-range tertiary interactions (loop L2-loop L3 and helix P2-loop L4)--all of this for the creation of a specific lysine binding site. We have determined that the interaction P2-L4 is particularly important for the organization of the ligand-bindi ...[more]