The filamins: organizers of cell structure and function.
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ABSTRACT:
SUBMITTER: Nakamura F
PROVIDER: S-EPMC3084982 | biostudies-literature | 2011 Mar-Apr
REPOSITORIES: biostudies-literature
Publications
The filamins: organizers of cell structure and function.
Nakamura Fumihiko F Stossel Thomas P TP Hartwig John H JH
Cell adhesion & migration 20110301 2
Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in 1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered its isoforms (FLNb and c), and identified over 90 binding partners including channels, receptors, intracellular signaling molecules, and even transcription factors. Due to this diversity, mutations in human FLN genes result in a wide range of anomalies with moderate to lethal consequences. This review focuse ...[more]
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