Ontology highlight
ABSTRACT:
SUBMITTER: Schopf CL
PROVIDER: S-EPMC8040823 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Schöpf Clemens L CL Ablinger Cornelia C Geisler Stefanie M SM Stanika Ruslan I RI Campiglio Marta M Kaufmann Walter A WA Nimmervoll Benedikt B Schlick Bettina B Brockhaus Johannes J Missler Markus M Shigemoto Ryuichi R Obermair Gerald J GJ
Proceedings of the National Academy of Sciences of the United States of America 20210401 14
In nerve cells the genes encoding for α<sub>2</sub>δ subunits of voltage-gated calcium channels have been linked to synaptic functions and neurological disease. Here we show that α<sub>2</sub>δ subunits are essential for the formation and organization of glutamatergic synapses. Using a cellular α<sub>2</sub>δ subunit triple-knockout/knockdown model, we demonstrate a failure in presynaptic differentiation evidenced by defective presynaptic calcium channel clustering and calcium influx, smaller pr ...[more]