Ontology highlight
ABSTRACT:
SUBMITTER: Shu T
PROVIDER: S-EPMC6969487 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Shu Tong T Jin Huaizhou H Rothman James E JE Zhang Yongli Y
Proceedings of the National Academy of Sciences of the United States of America 20191230 2
Munc13-1 is a large multifunctional protein essential for synaptic vesicle fusion and neurotransmitter release. Its dysfunction has been linked to many neurological disorders. Evidence suggests that the MUN domain of Munc13-1 collaborates with Munc18-1 to initiate SNARE assembly, thereby priming vesicles for fast calcium-triggered vesicle fusion. The underlying molecular mechanism, however, is poorly understood. Recently, it was found that Munc18-1 catalyzes neuronal SNARE assembly through an ob ...[more]