Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC6325239 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature communications 20190108 1
The transition of the Munc18-1/syntaxin-1 complex to the SNARE complex, a key step involved in exocytosis, is regulated by Munc13-1, SNAP-25 and synaptobrevin-2, but the underlying mechanism remains elusive. Here, we identify an interaction between Munc13-1 and the membrane-proximal linker region of synaptobrevin-2, and reveal its essential role in transition and exocytosis. Upon this interaction, Munc13-1 not only recruits synaptobrevin-2-embedded vesicles to the target membrane but also render ...[more]