Ontology highlight
ABSTRACT:
SUBMITTER: Shih JD
PROVIDER: S-EPMC3096038 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20110407 6
Systemic RNAi in Caenorhabditis elegans requires the widely conserved transmembrane protein SID-1 to transport RNAi silencing signals between cells. When expressed in Drosophila S2 cells, C. elegans SID-1 enables passive dsRNA uptake from the culture medium, suggesting that SID-1 functions as a channel for the transport of double-stranded RNA (dsRNA). Here we show that nucleic acid transport by SID-1 is specific for dsRNA and that addition of dsRNA to SID-1 expressing cells results in changes in ...[more]