Ontology highlight
ABSTRACT:
SUBMITTER: Whangbo JS
PROVIDER: S-EPMC5714486 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Whangbo Jennifer S JS Weisman Alexandra S AS Chae Jeiwook J Hunter Craig P CP
G3 (Bethesda, Md.) 20171204 12
In the nematode <i>Caenorhabditis elegans</i>, RNA interference (RNAi) triggered by double-stranded RNA (dsRNA) spreads systemically to cause gene silencing throughout the organism and its progeny. We confirm that <i>Caenorhabditis</i> nematode SID-1 orthologs have dsRNA transport activity and demonstrate that the SID-1 paralog CHUP-1 does not transport dsRNA. Sequence comparison of these similar proteins, in conjunction with analysis of loss-of-function missense alleles, identifies several cons ...[more]