Ontology highlight
ABSTRACT:
SUBMITTER: Hopper-Borge EA
PROVIDER: S-EPMC3096848 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Hopper-Borge Elizabeth A EA Churchill Timothy T Paulose Chelsy C Nicolas Emmanuelle E Jacobs Joely D JD Ngo Olivia O Kuang Yehong Y Grinberg Alex A Westphal Heiner H Chen Zhe-Sheng ZS Klein-Szanto Andres J AJ Belinsky Martin G MG Kruh Gary D GD
Cancer research 20110501 10
Recently, we reported that the ATP-binding cassette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer resistance to a variety of anticancer agents, including taxanes. However, the in vivo functions of the pump have not been determined to any extent. In this study, we generated and analyzed Abcc10(-/-) mice to investigate the ability of Abcc10 to function as an endogenous resistance factor. Mouse embryo fibroblasts derived from Abcc10(-/-) mice were h ...[more]