Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC7830771 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zhang Hui H Patel Atish A Wang Yi-Jun YJ Zhang Yun-Kai YK Kathawala Rishil J RJ Qiu Long-Hui LH Patel Bhargav A BA Huang Li-Hua LH Shukla Suneet S Yang Dong-Hua DH Ambudkar Suresh V SV Fu Li-Wu LW Chen Zhe-Sheng ZS
Molecular cancer therapeutics 20170306 6
Paclitaxel is one of the most widely used antineoplastic drugs in the clinic. Unfortunately, the occurrence of cellular resistance has limited its efficacy and application. The ATP-binding cassette subfamily B member 1 (ABCB1/P-glycoprotein) and subfamily C member 10 (ABCC10/MRP7) are the major membrane protein transporters responsible for the efflux of paclitaxel, constituting one of the most important mechanisms of paclitaxel resistance. Here, we demonstrated that the Bruton tyrosine kinase in ...[more]