Ontology highlight
ABSTRACT:
SUBMITTER: Chen JJ
PROVIDER: S-EPMC3775757 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chen Jun-Jiang JJ Patel Atish A Sodani Kamlesh K Xiao Zhi-Jie ZJ Tiwari Amit K AK Tiwari Amit K AK Zhang Dong-Mei DM Li Ying-Jie YJ Yang Dong-Hua DH Ye Wen-Cai WC Chen Si-Dong SD Chen Zhe-Sheng ZS
PloS one 20130917 9
Natural products are frequently used for adjuvant chemotherapy in cancer treatment. 23-O-(1,4'-bipiperidine-1-carbonyl) betulinic acid (BBA) is a synthetic derivative of 23-hydroxybutulinic acid (23-HBA), which is a natural pentacyclic triterpene and the major active constituent of the root of Pulsatillachinensis. We previously reported that BBA could reverse P-glycoprotein (P-gp/ABCB1)-mediated multidrug resistance (MDR). In the present study, we investigated whether BBA has the potential to re ...[more]