Ontology highlight
ABSTRACT:
SUBMITTER: Shema E
PROVIDER: S-EPMC3099049 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Molecular cell 20110501 4
hBRE1/RNF20 is the major E3 ubiquitin ligase for histone H2B. RNF20 depletion causes a global reduction of monoubiquitylated H2B (H2Bub) levels and augments the expression of growth-promoting, pro-oncogenic genes. Those genes reside preferentially in compact chromatin and are inefficiently transcribed under basal conditions. We now report that RNF20, presumably via H2Bub, selectively represses those genes by interfering with chromatin recruitment of TFIIS, a factor capable of relieving stalled R ...[more]