Ontology highlight
ABSTRACT:
SUBMITTER: Crich D
PROVIDER: S-EPMC3102264 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20090301 6
A new benzyl ether-type protecting group for alcohols, the 4-(tert-butyldiphenylsiloxy)-3-fluorobenzyl group, is introduced. The protecting group is introduced by means of the readily prepared benzyl bromide and is cleaved with tetrabutylammonium fluoride in dimethylformamide under microwave irradiation. The fluoride substituent provides stability to oxidizing conditions, such that the new protecting group is fully compatible with the removal of p-methoxybenzyl ethers with DDQ. Applications of t ...[more]