Ontology highlight
ABSTRACT:
SUBMITTER: Haddad D
PROVIDER: S-EPMC3102270 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Haddad Dania D Oruc Zéliha Z Puget Nadine N Laviolette-Malirat Nathalie N Philippe Magali M Carrion Claire C Le Bert Marc M Khamlichi Ahmed Amine AA
The EMBO journal 20110304 8
Class switch recombination (CSR) occurs between highly repetitive sequences called switch (S) regions and is initiated by activation-induced cytidine deaminase (AID). CSR is preceded by a bidirectional transcription of S regions but the relative importance of sense and antisense transcription for CSR in vivo is unknown. We generated three mouse lines in which we attempted a premature termination of transcriptional elongation by inserting bidirectional transcription terminators upstream of Sμ, up ...[more]