Ontology highlight
ABSTRACT:
SUBMITTER: Zarrin AA
PROVIDER: S-EPMC548964 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Zarrin Ali A AA Tian Ming M Wang Jing J Borjeson Tiffany T Alt Frederick W FW
Proceedings of the National Academy of Sciences of the United States of America 20050131 7
The class and effector functions of antibodies are modulated through the process of Ig heavy chain class switch recombination (CSR). CSR occurs between switch (S) regions that lie upstream of the various Ig heavy chain constant region exons. Molecular analyses of S-region functions have been hampered by their large size and repetitive nature. To test potential relationships between S-region size and efficiency of CSR, we generated normal B lymphocytes in which the 12-kb S region flanking the Cga ...[more]