Ontology highlight
ABSTRACT:
SUBMITTER: Thomas-Claudepierre AS
PROVIDER: S-EPMC3832931 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Thomas-Claudepierre Anne-Sophie AS Schiavo Ebe E Heyer Vincent V Fournier Marjorie M Page Adeline A Robert Isabelle I Reina-San-Martin Bernardo B
The Journal of experimental medicine 20131021 12
Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation-induced cytidine deaminase (AID) to switch regions and by the subsequent generation of double-stranded DNA breaks (DSBs). These DNA breaks are ultimately resolved through the nonhomologous end joining (NHEJ) pathway. We show that during CSR, AID associates with subunits of cohesin, a complex previously implicated in sister chromatid cohesion, DNA repair, and the formation of D ...[more]