Ontology highlight
ABSTRACT:
SUBMITTER: Taxman DJ
PROVIDER: S-EPMC3103340 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Taxman Debra J DJ Holley-Guthrie Elizabeth A EA Huang Max Tze-Han MT Moore Chris B CB Bergstralh Daniel T DT Allen Irving C IC Lei Yu Y Gris Denis D Ting Jenny Pan-Yun JP
The Journal of biological chemistry 20110412 22
ASC/PYCARD is a common adaptor for a diverse set of inflammasomes that activate caspase-1, most prominently the NLR-based inflammasome. Mounting evidence indicates that ASC and these NLRs also elicit non-overlapping functions, but the molecular basis for this difference is unclear. To address this, we performed microarray and network analysis of ASC shRNA knockdown cells. In pathogen-infected cells, an ASC-dependent interactome is centered on the mitogen-activated protein kinase (MAPK) ERK and o ...[more]