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Intramolecular alkene carboamination reactions for the synthesis of enantiomerically enriched tropane derivatives.

ABSTRACT: The synthesis of tropane derivatives via intramolecular Pd-catalyzed alkene difunctionalization reactions is described. Enantiopure N-aryl-?-aminoalkenes bearing an aryl or alkenyl halide adjacent to the amino group were converted to benzo- or cycloalkenyl-fused tropane products in good yield and with no loss of enantiopurity.

SUBMITTER: Schultz DM

PROVIDER: S-EPMC3103612 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Intramolecular alkene carboamination reactions for the synthesis of enantiomerically enriched tropane derivatives.

Schultz Danielle M DM Wolfe John P JP

Organic letters 20110511 11

The synthesis of tropane derivatives via intramolecular Pd-catalyzed alkene difunctionalization reactions is described. Enantiopure N-aryl-γ-aminoalkenes bearing an aryl or alkenyl halide adjacent to the amino group were converted to benzo- or cycloalkenyl-fused tropane products in good yield and with no loss of enantiopurity. ...[more]

PMID: 21561145

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