Ontology highlight
ABSTRACT:
SUBMITTER: Christodoulou C
PROVIDER: S-EPMC3104741 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Christodoulou Constantina C Longmire Tyler A TA Shen Steven S SS Bourdon Alice A Sommer Cesar A CA Gadue Paul P Spira Avrum A Gouon-Evans Valerie V Murphy George J GJ Mostoslavsky Gustavo G Kotton Darrell N DN
The Journal of clinical investigation 20110502 6
The directed differentiation of iPS and ES cells into definitive endoderm (DE) would allow the derivation of otherwise inaccessible progenitors for endodermal tissues. However, a global comparison of the relative equivalency of DE derived from iPS and ES populations has not been performed. Recent reports of molecular differences between iPS and ES cells have raised uncertainty as to whether iPS cells could generate autologous endodermal lineages in vitro. Here, we show that both mouse iPS and pa ...[more]