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A computer program for aligning a cDNA sequence with a genomic DNA sequence.


ABSTRACT: We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

SUBMITTER: Florea L 

PROVIDER: S-EPMC310774 | biostudies-literature | 1998 Sep

REPOSITORIES: biostudies-literature

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A computer program for aligning a cDNA sequence with a genomic DNA sequence.

Florea L L   Hartzell G G   Zhang Z Z   Rubin G M GM   Miller W W  

Genome research 19980901 9


We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation. ...[more]

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