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On the synthesis of conformationally modified peptides through isonitrile chemistry: implications for dealing with polypeptide aggregation.

ABSTRACT: A method for introducing a dimethyleneoxy constraint joining the N atoms of two consecutive amino acids in the context of a polypeptide has been developed. This constraint can profoundly affect the tendency of a polypeptide to suffer aggregation and desolubilization, and it can be readily removed under mild conditions.

SUBMITTER: Wu X

PROVIDER: S-EPMC3108857 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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On the synthesis of conformationally modified peptides through isonitrile chemistry: implications for dealing with polypeptide aggregation.

Wu Xiangyang X Park Peter K PK Danishefsky Samuel J SJ

Journal of the American Chemical Society 20110503 20

A method for introducing a dimethyleneoxy constraint joining the N atoms of two consecutive amino acids in the context of a polypeptide has been developed. This constraint can profoundly affect the tendency of a polypeptide to suffer aggregation and desolubilization, and it can be readily removed under mild conditions. ...[more]

PMID: 21539308

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