Ontology highlight
ABSTRACT:
SUBMITTER: Le RQ
PROVIDER: S-EPMC3109546 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Le Robert Quan RQ Melenhorst J Joseph JJ Battiwalla Minoo M Hill Brenna B Memon Sarfraz S Savani Bipin N BN Shenoy Aarthi A Hensel Nancy F NF Koklanaris Eleftheria K EK Keyvanfar Keyvan K Hakim Frances T FT Douek Daniel C DC Barrett A John AJ
Blood 20110318 19
After allogeneic stem cell transplantation (SCT), T lymphocyte function is reestablished from the donor's postthymic T cells and through thymic T-cell neogenesis. The immune repertoire and its relation to that of the donor have not been characterized in detail in long-term adult SCT survivors. We studied 21 healthy patients in their second decade after a myeloablative SCT for hematologic malignancy (median follow-up, 12 years). Immune profiles were compared with donor samples cryopreserved at tr ...[more]