Ontology highlight
ABSTRACT:
SUBMITTER: Zhu HH
PROVIDER: S-EPMC3109710 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Zhu Helen He HH Ji Kaihong K Alderson Nazilla N He Zhao Z Li Shuangwei S Liu Wen W Zhang Dong-Er DE Li Linheng L Feng Gen-Sheng GS
Blood 20110330 20
The stem cell factor (SCF)/Kit system has served as a classic model in deciphering molecular signaling events in the hematopoietic compartment, and Kit expression is a most critical marker for hematopoietic stem cells (HSCs) and progenitors. However, it remains to be elucidated how Kit expression is regulated in HSCs. Herein we report that a cytoplasmic tyrosine phosphatase Shp2, acting downstream of Kit and other RTKs, promotes Kit gene expression, constituting a Kit-Shp2-Kit signaling axis. In ...[more]