Ontology highlight
ABSTRACT:
SUBMITTER: You L
PROVIDER: S-EPMC3114437 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20110317 10
A library of quinoxaline derivatives were prepared to target non-structural protein 1 of influenza A (NS1A) as a means to develop anti-influenza drug leads. An in vitro fluorescence polarization assay demonstrated that these compounds disrupted the dsRNA-NS1A interaction to varying extents. Changes of substituent at positions 2, 3 and 6 on the quinoxaline ring led to variance in responses. The most active compounds (35 and 44) had IC(50) values in the range of low micromolar concentration withou ...[more]