Ontology highlight
ABSTRACT:
SUBMITTER: Hulme AE
PROVIDER: S-EPMC3116424 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Hulme Amy E AE Perez Omar O Hope Thomas J TJ
Proceedings of the National Academy of Sciences of the United States of America 20110531 24
During the early stages of HIV-1 replication the conical capsid composed of p24(CA) protein dissociates from the rest of the cytoplasmic viral complex by a process called uncoating. Although proper uncoating is known to be required for HIV-1 infection, many questions remain about the timing and factors involved in the process. Here we have used two complementary assays to study the process of uncoating in HIV-1-infected cells, specifically looking at the timing of uncoating and its relationship ...[more]