Ontology highlight
ABSTRACT:
SUBMITTER: Behrens S
PROVIDER: S-EPMC3119604 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Journal of computational biology : a journal of computational molecular cell biology 20101201 12
To gain a better understanding of the evolutionary dynamics of regulatory DNA sequences, we address the following questions: (1) How long does it take until a given transcription factor (TF) binding site emerges at random in a promoter sequence? and (2) How does the composition of a TF binding site affect this waiting time? Using two different probabilistic models (an i.i.d. model and a neighbor dependent model), we can compute the expected waiting time for every k-mer, k ranging from 5 to 10, u ...[more]