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Emergence of disseminated infections due to Geosmithia argillacea in patients with chronic granulomatous disease receiving long-term azole antifungal prophylaxis.


ABSTRACT: We report two cases of invasive infections due to Geosmithia argillacea, an emerging mold, in patients with chronic granulomatous disease receiving prolonged azole antifungal prophylaxis. One patient died despite receiving a combination of four antifungals, and the other developed cerebral and medullary lesions under a combination of caspofungin, posaconazole, terbinafine, and gamma interferon.

SUBMITTER: Machouart M 

PROVIDER: S-EPMC3122873 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Emergence of disseminated infections due to Geosmithia argillacea in patients with chronic granulomatous disease receiving long-term azole antifungal prophylaxis.

Machouart Marie M   Garcia-Hermoso Dea D   Rivier Alexandre A   Hassouni Noura N   Catherinot Emilie E   Salmon Alexandra A   Debourgogne Anne A   Coignard Hélène H   Lecuit Marc M   Bougnoux Marie-Elisabeth ME   Blanche Stéphane S   Lortholary Olivier O  

Journal of clinical microbiology 20110126 4


We report two cases of invasive infections due to Geosmithia argillacea, an emerging mold, in patients with chronic granulomatous disease receiving prolonged azole antifungal prophylaxis. One patient died despite receiving a combination of four antifungals, and the other developed cerebral and medullary lesions under a combination of caspofungin, posaconazole, terbinafine, and gamma interferon. ...[more]

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