Ontology highlight
ABSTRACT:
SUBMITTER: Xu T
PROVIDER: S-EPMC3123037 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20110512 26
Th17 cells have recently emerged as a major player in inflammatory and autoimmune diseases via the production of pro-inflammatory cytokines IL-17, IL-17F, and IL-22. The differentiation of Th17 cells and the associated cytokine production is directly controlled by RORγt. Here we show that ursolic acid (UA), a small molecule present in herbal medicine, selectively and effectively inhibits the function of RORγt, resulting in greatly decreased IL-17 expression in both developing and differentiated ...[more]