Ontology highlight
ABSTRACT:
SUBMITTER: Jones PM
PROVIDER: S-EPMC3123983 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Jones Peter M PM George Anthony M AM
Biophysical journal 20110601 12
ATP-binding cassette transporters use the energy of ATP hydrolysis to transport substrates across cellular membranes. They have two transmembrane domains and two cytosolic nucleotide-binding domains. Biochemical studies have characterized an occluded state of the transporter in which nucleotide is tenaciously bound in one active site, whereas the opposite active site is empty or binds nucleotide loosely. Here, we report molecular-dynamics simulations of the bacterial multidrug ATP-binding casset ...[more]