Ontology highlight
ABSTRACT:
SUBMITTER: Xing S
PROVIDER: S-EPMC3126325 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Xing Sifei S Bullen Cynthia K CK Shroff Neeta S NS Shan Liang L Yang Hung-Chih HC Manucci Jordyn L JL Bhat Shridhar S Zhang Hao H Margolick Joseph B JB Quinn Thomas C TC Margolis David M DM Siliciano Janet D JD Siliciano Robert F RF
Journal of virology 20110406 12
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the latent reservoir in resting CD4(+) cells, HAART is not curative. Elimination of this reservoir is critical to curing HIV-1 infection. Agents that reactivate latent HIV-1 through nonspecific T cell activation are toxic. Here we demonstrate in a primary CD4(+) T cell model that the FDA-approved drug disulfiram reactivates latent HIV-1 without global T cell activation. The e ...[more]