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Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.


ABSTRACT: Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the latent reservoir in resting CD4(+) cells, HAART is not curative. Elimination of this reservoir is critical to curing HIV-1 infection. Agents that reactivate latent HIV-1 through nonspecific T cell activation are toxic. Here we demonstrate in a primary CD4(+) T cell model that the FDA-approved drug disulfiram reactivates latent HIV-1 without global T cell activation. The extent to which disulfiram reactivates latent HIV-1 in patient cells is unclear, but the drug alone or in combination may be useful in future eradication strategies.

SUBMITTER: Xing S 

PROVIDER: S-EPMC3126325 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

Xing Sifei S   Bullen Cynthia K CK   Shroff Neeta S NS   Shan Liang L   Yang Hung-Chih HC   Manucci Jordyn L JL   Bhat Shridhar S   Zhang Hao H   Margolick Joseph B JB   Quinn Thomas C TC   Margolis David M DM   Siliciano Janet D JD   Siliciano Robert F RF  

Journal of virology 20110406 12


Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the latent reservoir in resting CD4(+) cells, HAART is not curative. Elimination of this reservoir is critical to curing HIV-1 infection. Agents that reactivate latent HIV-1 through nonspecific T cell activation are toxic. Here we demonstrate in a primary CD4(+) T cell model that the FDA-approved drug disulfiram reactivates latent HIV-1 without global T cell activation. The e  ...[more]

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