Ontology highlight
ABSTRACT:
SUBMITTER: Romani B
PROVIDER: S-EPMC4994036 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20160823
HIV-1 Vpr is an accessory protein that induces proteasomal degradation of multiple proteins. We recently showed that Vpr targets class I HDACs on chromatin for proteasomal degradation. Here we show that Vpr induces degradation of HDAC1 and HDAC3 in HIV-1 latently infected J-Lat cells. Degradation of HDAC1 and HDAC3 was also observed on the HIV-1 LTR and as a result, markers of active transcription were recruited to the viral promoter and induced viral activation. Knockdown of HDAC1 and HDAC3 act ...[more]