Ontology highlight
ABSTRACT:
SUBMITTER: Avdic S
PROVIDER: S-EPMC3126599 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Avdic Selmir S Cao John Z JZ Cheung Allen K L AK Abendroth Allison A Slobedman Barry B
Journal of virology 20110518 14
The human cytomegalovirus UL111A gene is expressed during latent and productive infections, and it codes for homologs of interleukin-10 (IL-10). We examined whether viral IL-10 expressed during latency altered differentiation of latently infected myeloid progenitors. In comparison to infection with parental virus or mock infection, latent infection with a virus in which the gene encoding viral IL-10 has been deleted upregulated cytokines associated with dendritic cell (DC) formation and increase ...[more]