Ontology highlight
ABSTRACT:
SUBMITTER: Chang FY
PROVIDER: S-EPMC3126909 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Chang Fang-Yuan FY Brady Sean F SF
Journal of the American Chemical Society 20110504 26
Soil is predicted to contain thousands of unique bacterial species per gram. Soil DNA libraries represent large reservoirs of biosynthetic diversity from which diverse secondary metabolite gene clusters can be recovered and studied. The screening of an archived soil DNA library using primers designed to target oxytryptophan dimerization genes allowed us to identify and functionally characterize the first indolotryptoline biosynthetic gene cluster. The recovery and heterologous expression of an e ...[more]