Ontology highlight
ABSTRACT:
SUBMITTER: Hooi MY
PROVIDER: S-EPMC3127471 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Hooi Michelle Yu Sung MY Truscott Roger J W RJ
Age (Dordrecht, Netherlands) 20100805 2
ASTRACT: Several amino acids were found to undergo progressive age-dependent racemisation in the lifelong proteins of normal human lenses. The two most highly racemised were Ser and Asx. By age 70, 4.5% of all Ser residues had been racemised, along with >9% of Asx residues. Such a high level of inversion, equivalent to between 2 and 3 D- amino acids per polypeptide chain, is likely to induce significant denaturation of the crystallins in aged lenses. Thr, Glx and Phe underwent age-dependent race ...[more]