Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.
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ABSTRACT:
SUBMITTER: Fortwendel JR
PROVIDER: S-EPMC3127644 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.
Fortwendel Jarrod R JR Juvvadi Praveen R PR Rogg Luise E LE Steinbach William J WJ
Eukaryotic cell 20110128 4
Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi. ...[more]
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