Ontology highlight
ABSTRACT:
SUBMITTER: Kamishikiryo J
PROVIDER: S-EPMC3129164 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Kamishikiryo Jun J Fukuhara Hideo H Okabe Yuki Y Kuroki Kimiko K Maenaka Katsumi K
The Journal of biological chemistry 20110513 27
Human Th17 cells express high levels of CD161, a member of the killer cell lectin-like receptor (KLR) family (also referred to as NK receptor-P1A (NKRP1A) or KLRB1), as a representative marker. CD161 is also expressed on natural killer (NK) cells and NKT cells. Lectin-like transcript 1 (LLT1), another KLR family member, was recently identified as a ligand for CD161. This interaction may play pivotal roles in the immunomodulatory functions of Th17 cells as well as those of NK and NKT cells. Howev ...[more]