Ontology highlight
ABSTRACT:
SUBMITTER: Shu Y
PROVIDER: S-EPMC3129561 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Shu Yi Y Cinier Mathieu M Fox Sejal R SR Ben-Johnathan Nira N Guo Peixuan P
Molecular therapy : the journal of the American Society of Gene Therapy 20110405 7
The 117-nucleotide (nt) RNA, called the packaging RNA (pRNA) of bacteriophage phi29 DNA packaging motor, has been shown to be an efficient vector for the construction of RNA nanoparticles for the delivery of small interfering RNA (siRNA) into specific cancer or viral-infected cells. Currently, chemical synthesis of 117-nt RNA is not feasible commercially. In addition, labeling at specific locations on pRNA requires the understanding of its modular organization. Here, we report multiple approache ...[more]