Ontology highlight
ABSTRACT:
SUBMITTER: Potthoff MJ
PROVIDER: S-EPMC3131185 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Potthoff Matthew J MJ Boney-Montoya Jamie J Choi Mihwa M He Tianteng T Sunny Nishanth E NE Satapati Santhosh S Suino-Powell Kelly K Xu H Eric HE Gerard Robert D RD Finck Brian N BN Burgess Shawn C SC Mangelsdorf David J DJ Kliewer Steven A SA
Cell metabolism 20110601 6
Regulation of hepatic carbohydrate homeostasis is crucial for maintaining energy balance in the face of fluctuating nutrient availability. Here, we show that the hormone fibroblast growth factor 15/19 (FGF15/19), which is released postprandially from the small intestine, inhibits hepatic gluconeogenesis, like insulin. However, unlike insulin, which peaks in serum 15 min after feeding, FGF15/19 expression peaks approximately 45 min later, when bile acid concentrations increase in the small intest ...[more]