Crystal structure of the autochaperone region from the Shigella flexneri autotransporter IcsA.
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ABSTRACT:
SUBMITTER: Kuhnel K
PROVIDER: S-EPMC3133035 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Crystal structure of the autochaperone region from the Shigella flexneri autotransporter IcsA.
Kühnel Karin K Diezmann Dagmar D
Journal of bacteriology 20110218 8
The IcsA (intracellular spread gene A) autotransporter from Shigella flexneri is a key virulence factor. We identified a stable fragment comprising residues 591 to 758, which corresponds to the autochaperone region of the IcsA passenger domain. We showed that thermal unfolding of the autochaperone region is reversible and determined its crystal structure at 2.0-Å resolution. ...[more]
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