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Neogenin may functionally substitute for Dcc in chicken.

ABSTRACT: Dcc is the key receptor that mediates attractive responses of axonal growth cones to netrins, a family of axon guidance cues used throughout evolution. However, a Dcc homolog has not yet been identified in the chicken genome, raising the possibility that Dcc is not present in avians. Here we show that the closely related family member neogenin may functionally substitute for Dcc in the developing chicken spinal cord. The expression pattern of chicken neogenin in the developing spinal cord is a composite of the distribution patterns of both rodent Dcc and neogenin. Moreover, whereas the loss of mouse neogenin has no effect on the trajectory of commissural axons, removing chicken neogenin by RNA interference results in a phenotype similar to the functional inactivation of Dcc in mouse. Taken together, these data suggest that the chick neogenin is functionally equivalent to rodent Dcc.

SUBMITTER: Phan KD

PROVIDER: S-EPMC3133656 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Neogenin may functionally substitute for Dcc in chicken.

Phan Keith Dai KD Croteau Louis-Philippe LP Kam Joseph Wai Keung JW Kania Artur A Cloutier Jean-François JF Butler Samantha Joanna SJ

PloS one 20110711 7

Dcc is the key receptor that mediates attractive responses of axonal growth cones to netrins, a family of axon guidance cues used throughout evolution. However, a Dcc homolog has not yet been identified in the chicken genome, raising the possibility that Dcc is not present in avians. Here we show that the closely related family member neogenin may functionally substitute for Dcc in the developing chicken spinal cord. The expression pattern of chicken neogenin in the developing spinal cord is a c ...[more]

PMID: 21779375

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