Ontology highlight
ABSTRACT:
SUBMITTER: Tian C
PROVIDER: S-EPMC3775419 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Tian Chenxi C Shi Herong H Xiong Shan S Hu Fenghua F Xiong Wen-Cheng WC Liu Jun J
Development (Cambridge, England) 20130904 19
The deleted in colorectal cancer (DCC) homolog neogenin functions in both netrin- and repulsive guidance molecule (RGM)-mediated axon guidance and in bone morphogenetic protein (BMP) signaling. How neogenin functions in mediating BMP signaling is not well understood. We show that the sole C. elegans DCC/neogenin homolog UNC-40 positively modulates a BMP-like pathway by functioning in the signal-receiving cells at the ligand/receptor level. This function of UNC-40 is independent of its role in ne ...[more]