Ontology highlight
ABSTRACT:
SUBMITTER: Campbell PJ
PROVIDER: S-EPMC3137369 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Campbell Peter J PJ Yachida Shinichi S Mudie Laura J LJ Stephens Philip J PJ Pleasance Erin D ED Stebbings Lucy A LA Morsberger Laura A LA Latimer Calli C McLaren Stuart S Lin Meng-Lay ML McBride David J DJ Varela Ignacio I Nik-Zainal Serena A SA Leroy Catherine C Jia Mingming M Menzies Andrew A Butler Adam P AP Teague Jon W JW Griffin Constance A CA Burton John J Swerdlow Harold H Quail Michael A MA Stratton Michael R MR Iacobuzio-Donahue Christine C Futreal P Andrew PA
Nature 20101001 7319
Pancreatic cancer is an aggressive malignancy with a five-year mortality of 97-98%, usually due to widespread metastatic disease. Previous studies indicate that this disease has a complex genomic landscape, with frequent copy number changes and point mutations, but genomic rearrangements have not been characterized in detail. Despite the clinical importance of metastasis, there remain fundamental questions about the clonal structures of metastatic tumours, including phylogenetic relationships am ...[more]