Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.
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ABSTRACT:
SUBMITTER: Yamanaka K
PROVIDER: S-EPMC3137510 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.
Yamanaka Koji K Chun Seung Joo SJ Boillee Severine S Fujimori-Tonou Noriko N Yamashita Hirofumi H Gutmann David H DH Takahashi Ryosuke R Misawa Hidemi H Cleveland Don W DW
Nature neuroscience 20080203 3
Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease that is characterized by the loss of motor neurons. Using mice carrying a deletable mutant gene, diminished mutant expression in astrocytes did not affect onset, but delayed microglial activation and sharply slowed later disease progression. These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomo ...[more]
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