Ontology highlight
ABSTRACT:
SUBMITTER: Raspail C
PROVIDER: S-EPMC3138293 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Raspail Corinne C Graindorge Matthieu M Moreau Yohann Y Crouzy Serge S Lefèbvre Bertrand B Robin Adeline Y AY Dumas Renaud R Matringe Michel M
The Journal of biological chemistry 20110525 29
4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) into homogentisate. HPPD is the molecular target of very effective synthetic herbicides. HPPD inhibitors may also be useful in treating life-threatening tyrosinemia type I and are currently in trials for treatment of Parkinson disease. The reaction mechanism of this key enzyme in both plants and animals has not yet been fully elucidated. In this study, using site-directed mutagenesis supported by ...[more]