Ontology highlight
ABSTRACT:
SUBMITTER: Zhang K
PROVIDER: S-EPMC3138866 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Zhang Kaihua K Kim Seokho S Cremasco Viviana V Hirbe Angela C AC Collins Lynne L Piwnica-Worms David D Novack Deborah V DV Weilbaecher Katherine K Faccio Roberta R
Cancer research 20110520 14
Blockade of osteoclast (OC) activity efficiently decreases tumor burden as well as associated bone erosion in immune-compromised animals bearing human osteolytic cancers. In this study, we showed that modulation of antitumor T-cell responses alters tumor growth in bone, regardless of OC status, by using genetic and pharmacologic models. PLCγ2(-/-) mice, with dysfunctional OCs and impaired dendritic cell (DC)-mediated T-cell activation, had increased bone tumor burden despite protection from bone ...[more]