Ontology highlight
ABSTRACT:
SUBMITTER: Shibata N
PROVIDER: S-EPMC3139182 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Shibata Nobuto N Ohnuma Tohru T Kuerban Bolati B Komatsu Miwa M Baba Hajime H Arai Heii H
International journal of Alzheimer's disease 20110714
A recent paper reported that Aβ oligomer causes neuronal cell death through the phosphatidylinositol-3-OH kinase (PI3K)-Akt-mTOR signaling pathway. Intraneuronal Aβ, a main pathological finding of Alzheimer's disease (AD), is also known as inhibiting activation of Akt. This study aims to investigate whether single nucleotide polymorphisms (SNPs) of the Akt1 gene are associated with AD. SNPs genotyped using TaqMan technology was analyzed using a case-control study design. Our case-control dataset ...[more]