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Genetic Association between Neurotrophin-3 Polymorphisms and Alzheimer's Disease in Japanese Patients.


ABSTRACT: BACKGROUND:Some polymorphisms of the neurotrophin family have previously been investigated as candidate genes for Alzheimer's disease (AD). In the present study, we examined whether neurotrophin-3 (NTF-3) polymorphisms are genetic risk factors in patients with AD. METHODS:From a sample of 507 subjects, we recruited 248 age-matched subjects divided into 2 groups: AD patients (n = 143) and normal controls (NCs) (n = 105). We identified 3 representative NTF-3 single nucleotide polymorphisms (SNPs): rs6332, rs6489630, and rs4930767. Next, we statistically compared the allele frequencies of each SNP between the AD and NC groups in the early-onset (<65 years) cases under a more limited age-matched condition. RESULTS:We found a significant association between rs6332 and the total group of AD patients (p = 0.013) and significant associations between both rs6332 (p = 0.033) and rs6489630 (p = 0.035) and early-onset AD patients. CONCLUSION:These results suggest that NTF-3 SNPs may not only be associated with AD itself, but also with early-onset AD in Japanese patients, assuming that the NTF-3 gene may have age-related effects on neurodegenerative diseases.

SUBMITTER: Nagata T 

PROVIDER: S-EPMC3808222 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Genetic Association between Neurotrophin-3 Polymorphisms and Alzheimer's Disease in Japanese Patients.

Nagata Tomoyuki T   Shibata Nobuto N   Shinagawa Shunichiro S   Nakayama Ritsuko R   Kuerban Bolati B   Ohnuma Tohru T   Arai Heii H   Nakayama Kazuhiko K   Yamada Hisashi H  

Dementia and geriatric cognitive disorders extra 20130907 1


<h4>Background</h4>Some polymorphisms of the neurotrophin family have previously been investigated as candidate genes for Alzheimer's disease (AD). In the present study, we examined whether neurotrophin-3 (NTF-3) polymorphisms are genetic risk factors in patients with AD.<h4>Methods</h4>From a sample of 507 subjects, we recruited 248 age-matched subjects divided into 2 groups: AD patients (n = 143) and normal controls (NCs) (n = 105). We identified 3 representative NTF-3 single nucleotide polymo  ...[more]

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