Ontology highlight
ABSTRACT:
SUBMITTER: Boles NC
PROVIDER: S-EPMC3139389 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Blood 20110516 1
The proliferation and differentiation of adult stem cells is balanced to ensure adequate generation of differentiated cells, stem cell homeostasis, and guard against malignant transformation. CD48 is broadly expressed on hematopoietic cells but excluded from quiescent long-term murine HSCs. Through its interactions with CD244 on progenitor cells, it influences HSC function by altering the BM cytokine milieu, particularly IFNγ. In CD48-null mice, the resultant misregulation of cytokine signaling ...[more]