Ontology highlight
ABSTRACT:
SUBMITTER: Makeyev EV
PROVIDER: S-EPMC3139456 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Makeyev Eugene V EV Zhang Jiangwen J Carrasco Monica A MA Maniatis Tom T
Molecular cell 20070801 3
Both microRNAs and alternative pre-mRNA splicing have been implicated in the development of the nervous system (NS), but functional interactions between these two pathways are poorly understood. We demonstrate that the neuron-specific microRNA miR-124 directly targets PTBP1 (PTB/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in nonneuronal cells. Among the targets of PTBP1 is a critical cassette exon in the pre-mRNA of PTBP2 (nPTB/brPTB/PTBLP), an NS-enriched PT ...[more]